Todd Subritzky, PhD

Historical use of cannabis for medicinal purposes

The use of cannabis and hemp oil for medicinal purposes has a long history that extends beyond historical records, so we simply don’t know when the practice originated.

The earliest accounts are to be found in the Shennong Ben Cao Jing, a Chinese book on medicinal plants and agriculture, which is thought to have been compiled from the oral tradition starting in 2700 BC (Russo, 2014; Shou-Zhong, 1997). The Shennong Ben Cao Jing noted that cannabis was hallucinatory and potentially useful for appetite stimulation and anti-senility effects.

In more recent times, that is from around 1840 – 1940, the use of cannabis for a range of medicinal purposes became a relatively mainstream and accepted activity in North America and Europe (Maccallum & Russo, 2018; Mikuriya, 2007). Indeed, “it is only in the last century that quality control issues, the lack of a defined chemistry, and above all, politically and ideologically motivated prohibition relegated cannabis as planta non grata” (Maccallum & Russo, 2018, p.12).

However, with the discovery of the endocannabinoid system (ECS) in the 1990s, scientists began to understand how cannabis and specific cannabinoids therapeutically influence the human body (Mechoulam, 2006). When discussing the therapeutic influence of cannabinoids, it is necessary to define terms. There are three distinct categories of cannabinoids including: (i) endocannabinoids (produced naturally within the human body and an integral component of the ECS); (ii) synthetic cannabinoids (molecules synthesized in laboratories); and (iii) phyto-cannabinoids, which are unique to the cannabis plant (Israeli Ministry of Health, 2018).  So to be clear, the following relates to the use of phyto-cannabinoids – products sourced from the cannabis plant.

Unfortunately, as noted in a previous interview, “physicians of the world remain profoundly uneducated with respect to cannabis and the endocannabinoid system (ECS) that underlies much of its activity” (Evanoff, Quan, Dufault, Awad, & Bierut, 2017; Maccallum & Russo, 2018, p.12). As such it is prudent that clinicians take a conservative approach that seeks to reduce adverse effects while unlocking therapeutic potential. Our recommendations are based on the latest developments by the world’s most experienced clinicians and researchers in the medical cannabis field including the world leading clinical guide to medical grade cannabis as developed by the Israeli Ministry of Health.

Let’s now take a look at:

Differences in cannabis products preparations, method of administration, dosing strategies, and patient tolerance.

Medical grade cannabis products and preparations

The genus cannabis sativa includes thousands of strains or varieties that contain different ratios of phyto-cannabinoids that impact the patient in different ways. Current best practice broadly categorizes cannabis products as either THC-rich or CBD-rich type products (Israeli Ministry of Health, 2018). Within these two groups, the three most common types of preparation include: (i) dried cannabis efflorescence (often referred to as herbal or ‘whole-plant’ cannabis, flower, or bud); (ii) cannabis oil extract; and (iii) edible cannabis products such as cookies.

Method of administration

How cannabis is consumed impacts on the pharmacokinetic profile of the medicine, which means that there are differences in the rate that cannabinoids absorb into the bloodstream according to how it is consumed.  Generally, the method of consumption relates to the preparation type.

Inhalation

Dried cannabis flower is usually inhaled either by smoking or vaporizing. With this method of consumption active constituents are absorbed into the bloodstream quickly via the lungs.

Sublingual administration

Cannabis oil extracts are generally intended for sublingual administration in which the substances are absorbed directly from the oral mucosa into the bloodstream. With this method, the process of metabolism in the liver and gastrointestinal tract is bypassed.

Oral administration

Cannabis edible products are intended for oral administration. In this process, cannabinoids enter the bloodstream via the gastrointestinal tract and therefore taking longer to activate cannabinoid receptors. This approach can be problematic in titrating the dose due to the delayed impact, so conservative dosing strategies are advised.

Patient dosing

There are now a number of dosing guidelines available that can assist both clinicians and patients in identifying optimal dosing strategies. According to Maccallum and Russo (2018), these include:

  • Start low and go slow
  • Regarding THC rich products, concentrated products may allow for the utilization of lower amounts
  • CBD can balance potential side effects that may be associated with THC rich products
  • Doses must be individually determined as the correct dose will depend on the ‘underlying endocannabinoid tone’.
  • CBD rich products have fewer psychotropic effects and therefore may need to be dosed in higher quantities.

 

References

Evanoff, A., Quan, T., Dufault, C., Awad, M., & Bierut, L. (2017). Physicians-in-training are not prepared to prescribe medical marijuana. Drug and Alcohol Dependence, 180, 151.

Israeli Ministry of Health. (2018). Medical Grade Cannabis – Clinical Guide (Green Book). Retrieved 2/2/2019 from https://www.xn--4dbcyzi5a.com/2018/01/medical-cannabis-official-israeli-clinical-guide/

Maccallum, C., & Russo, E. (2018). Practical considerations in medical cannabis administration and dosing. European Journal of Internal Medicine, 49, 12-19. doi:10.1016/j.ejim.2018.01.004

Mechoulam, R. (2006). Cannabinoids as Therapeutics. In Milestones in Drug Therapy. Basel, Switzerland: Birkhäuser Basel.

Mikuriya, T. H. (2007). Marijuana: Medical papers, 1839-1972. (Vol. one). Nevada City, CA: Symposium Publishing.

Russo, E. (2014). The pharmacological history of cannabis. In R. Pertwee (Ed.), Handbook of Cannabis (pp. 23-43). Oxford, UK: Oxford University Press.

Shou-Zhong, Y. (1997). The Devine Farmer’s Materia Medica: A Translation of the Shen Nong Ben Cao Jing. Boulder, Co: Blue Poppy Press.